Bacterial strain 1903 was isolated and purified from Solomon Islands marine sediment samples. From its morphological features, it was classified as a Streptomyces. The secondary metabolites of strain 1903 were extracted using EtOAc. Bioassay guided purification of the extract produced two known pure compounds; 5-deoxyenterocin and vulgamycin (also known as enterocin). Both compounds were strongly active against WTSA (MIC <1 µg/mL) and in BSA (MIC <1 µg/mL). 5-deoxyenterocin was also active against RRSA (MIC of 250 µg/mL) while vulgamycin showed bioactivity against MRSA (MIC of 250 µg/mL). This report contains the first bio-activity results of 5-deoxyenterocin to be recorded and the first bio-activity results of vulgamycin in brine shrimp assay to be reported.